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Here, in a nutshell, an illustration of the concept of "open borders" of the Weizmann Institute of Science. Research inshoku student is independent Shlomovitz from research by Prof. Nir Gov Department of Chemical Physics Chemistry Department, and recently won the award the award is in memory of Professor Lee A.. Theoretical biology faculty. Professor Segal, inshoku who died in 2005, was on the faculty of the Department of Mathematics at the Weizmann Institute of Science for many years, and was among the first who broke the boundaries that separate the mathematics of Life Sciences. His work has demonstrated that one can describe the task complexity of biological systems using mathematical models, and even taught biologists to reason mathematically. "My work just right approach outlined inshoku by Professor Segal," says Shlomovitz.
Shlomovitz and Prof. Gov. study the proteins that form the scaffolding holding the cell structure - skeleton inshoku - cells. These proteins - actin and myosin called - creating the fibers in our muscles, which contract during the effort, and they play a role in cell movement and division. When the cell moves, actin filaments assemble his front side, forming a kind of bulge that drags the cell forward. During cell division, actin filaments and Hmiosein form a ring in the center of the cell, and compressed the crust toward the center, until it was cut in half.
To answer these questions, watching Shlomovitz and Prof. Gov. activities of these proteins in cells, inshoku creating mathematical models based on observational data. They then examine the predictions obtained from the models by comparing observations made in other research groups on biological systems, such as yeast. According to their model, proteins actin and Hmiosein receive the order for their "Depending on the form of the molecules located on the cell membrane. When the cell has to move, the membrane indicates the way forward while increasing curve on one side. Those concave molecules "invite" the actin proteins assemble around them. As a result, large amounts of these molecules, together with actin, flocking to the site, and pushing the cell edge curved forward. However, the initial stages of cell division gets the membrane center concave shape. When scientists examined proteins in bacteria, found that the curved shape is also attracting proteins: protein ring sits just cut along the line of the cell, and marks the dividing line of the bacterium. inshoku
The mathematical model developed inshoku using two physical formula which describes the free energy of the system. Using the formula they calculated the dispersion of proteins in the membrane, and shown how this distribution depends on the shape of the membrane. Researchers have discovered how exactly causes the concave section of membrane proteins surround the exact center of the cell, how to increase the curve causes the site to attract other proteins and thus increase the compression strength, and how the distance between one protein neighbors determines whether inshoku they will join the shrinking belt or produce separate rings. inshoku The model created by scientists not only able to predict inshoku the behavior of these proteins inshoku in artificial inshoku membrane convex and concave. A group of researchers in Taiwan revealed, the model also explains the ripple shapes of the membranes of living cells. Shlomovitz: "We describe a complex biological inshoku processes taking place in a single cell by developing chemical and physical models. Mathematics is the 'language' in which we analyze them."
"We create theoretical models allow us to gain a deeper understanding about the forces underlying patterns and processes in a spontaneous Christians living cells - that is, the principles of self-organization, and create quantitative predictions," says Dr. gov. 'Main strength of mathematical inshoku models - such physical is their ability to shed light on the general inshoku principles - which behave in living cells. "
It's really impressive to combine so many sciences. I wonder what discipline to be interested in this study. Probably chemists, mathematicians and computer scientists will be interested less. Physicists and biologists doubt - may be interested inshoku but not clear how to understand.
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